Remove the selected options :
-----------------------------
$('#mySelect2').val(null).trigger('change');
============================================
Completly remove the select2 initialization :
--------------------------------------------
$('#payment_method').html('').select2({data: [{id: '', text: ''}]});<select id="lang" >
<option value="1">php</option>
<option value="2">asp</option>
<option value="3">java</option>
</select>
<script>
$("#lang").select2().select2('val','1');
</script>$('#mySelect').select2({
data: ['one','two'],
tags: true
});
$('#mySelect').val(['one','two']).trigger('change')$('#id :selected').text();$('#inputID').select2('data', {id: 100, a_key: 'Lorem Ipsum'});$('#all_contacts').select2('data', {id: '123', text: 'res_data.primary_email'});